ABSTRACT
Background: Organophosphorus insecticides are one of the most common causes of poisoning in India. It has a high mortality rate and accounts for a third of suicidal deaths in south-east Asia.Methods: The objectives were to estimate serum pseudocholinesterase and creatine phosphokinase (CPK) levels in organophosphorus poisoning and correlate them with theseverity and prognosis described by the Peradeniya organophosphorus poisoning (POP) scale at initial presentation.This was a cross-sectional study conducted over 18 months. A total of 180 organophosphorus-poisoning subjects were divided into mild, moderate and severe grades based on POP scale at admission. Serum pseudocholinesterase and CPK levels were estimated at admission. The outcome was noted, and the results were statistically analysed.Results:It was found that 112 (62.2%), 51 (28.3%) and 17 (9.4%) patients had mild, moderate and severe poisoning, respectively, according to POP scale. Mean pseudocholinesterase level (units/litre) was 2393.29, 1104.37 and 638.18 and mean serum CPK level (units/litre) was 153.41,344.94 and 280.53 in mild, moderate and severe poisoning, respectively. ICU and ventilator were required for 84 (46.75%) and 72 (40%) patients, respectively. Mortality was 17.8%. Negative, weak and significant correlation was seen between POP score and pseudocholinesterase (r=-0.265, p=0.00). Positive, moderate and significant correlation was seen between POP score and CPK levels (r=0.449, p=0.00).Conclusions: POP scale applied at admission along with serum pseudocholinesterase and CPK levels serve as a simple and effective system to determine early need for ventilation and mortality in rural, peripheral centres in developing nations.
ABSTRACT
Background: CPR is emerging as an important predictor of adverse pregnancy outcome and helps in management of high risk pregnancy. Therefore we undertook the study to find the correlation of CPR with perinatal outcomes in women with hypertensive disorder complicating during third trimester.Methods: 128 patients with hypertensive disorder of pregnancy, ≥32 weeks of singleton gestation, were randomly selected during their hospital visit. They were subjected to USG Doppler study to calculate MCA/UA pulsatility index-CPR. The CPR<1 was considered abnormal and >1 as normal. These results were compared with the perinatal outcome and adverse fetal outcome.Results: The present study revealed that the incidence of adverse outcomes like Apgar score <7 (36.5%), still birth (15.9%), NICU admission (69.8%) and LBW i.e. <2500 gm (68.3%) were significantly higher in abnormal CPR than normal CPR.Conclusions: Abnormal CPR is valuable in predicting the outcome of hypertensive disorders in pregnancy. CPR is an easy procedure which can be included in the routine antenatal sonographic evaluation to predict poor perinatal outcome and to detect or recognize those fetuses at risk.